UGT1A1 Antibody
| Code | Size | Price |
|---|
| PSI-57-373-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
UDP-glucuronosyltransferase 1-1, UDPGT 1-1, UGT1*1, UGT1-01, UGT11, Bilirubin-specific UDPGT isozyme 1, hUG-BR1, UDP-glucuronosyltransferase 1-A, UGT-1A, UGT1A, UDP-glucuronosyltransferase 1A1, UGT1A1, GNT1, UGT1
Application Note:
For WB starting dilution is: 1:1000
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a UDP-glucuronosyltransferase, an enzyme
of the glucuronidation pathway that transforms small lipophilic
molecules, such as steroids, bilirubin, hormones, and drugs, into
water-soluble, excretable metabolites. This gene is part of a
complex locus that encodes several UDP-glucuronosyltransferases.
The locus includes thirteen unique alternate first exons followed
by four common exons. Four of the alternate first exons are
considered pseudogenes. Each of the remaining nine 5' exons may be
spliced to the four common exons, resulting in nine proteins with
different N-termini and identical C-termini. Each first exon
encodes the substrate binding site, and is regulated by its own
promoter. The preferred substrate of this enzyme is bilirubin,
although it also has moderate activity with simple phenols,
flavones, and C18 steroids. Mutations in this gene result in
Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Background References:
- Italia, K.Y., et al. Clin. Biochem. 43 (16-17), 1329-1332 (2010) :
- Justenhoven, C., et al. Breast Cancer Res. Treat. 124(1):289-292(2010)
- Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
- Sai, K., et al. BrClin Pharmacol 70(2):222-233(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UGT1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-90 amino acids from the N-terminal region of human UGT1A1.
NCBI Gene ID #:
54658
NCBI Official Name:
UDP-glucuronosyltransferase 1-1
NCBI Official Symbol:
UGT1A1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
P22309
Protein GI Number:
136729
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P22309
User NOte:
Optimal dilutions for each application to be determined by the researcher.