ARHGEF11 Antibody
| Code | Size | Price |
|---|
| PSI-58-813-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF, ARHGEF11, KIAA0380
Application Note:
For WB starting dilution is: 1:1000
Background:
Rho GTPases play a fundamental role in numerous cellular
processes that are initiated by extracellular stimuli that work
through G protein coupled receptors. The encoded protein may form a
complex with G proteins and stimulate Rho-dependent signals. A
similar protein in rat interacts with glutamate transporter EAAT4
and modulates its glutamate transport activity. Expression of the
rat protein induces the reorganization of the actin cytoskeleton
and its overexpression induces the formation of membrane ruffling
and filopodia. Two alternative transcripts encoding different
isoforms have been described.
Background References:
- Akiyama, K., et al. J. Hum. Genet. (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Ying, Z., et al. Arterioscler. Thromb. Vasc. Biol. 29(10):1657-1663(2009)
- Banerjee, J., et al. Biochemistry 48(33):8032-8043(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This ARHGEF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 605-632 amino acids from the Central region of human ARHGEF11.
NCBI Gene ID #:
9826
NCBI Official Name:
Rho guanine nucleotide exchange factor 11
NCBI Official Symbol:
ARHGEF11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
168 kDa
Protein Accession #:
O15085
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O15085
User NOte:
Optimal dilutions for each application to be determined by the researcher.