TLE1 Antibody
| Code | Size | Price |
|---|
| PSI-64-027-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transducin-like enhancer protein 1, E(Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1
Application Note:
For WB starting dilution is: 1:1000
Background:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Background References:
- Ali, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(9):4165-4169(2010)
- Jagdis, A., et al. Am. J. Surg. Pathol. 33(12):1743-1751(2009)
- Kosemehmetoglu, K., et al. Mod. Pathol. 22(7):872-878(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This TLE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the Central region of human TLE1.
NCBI Gene ID #:
7088
NCBI Official Name:
Transducin-like enhancer protein 1
NCBI Official Symbol:
TLE1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
Q04724
Protein GI Number:
29840816
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q04724
User NOte:
Optimal dilutions for each application to be determined by the researcher.