DUSP10 Antibody
| Code | Size | Price |
|---|
| PSI-60-804-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5, MAP kinase phosphatase 5, MKP-5, DUSP10, MKP5
Application Note:
For WB starting dilution is: 1:1000
Background:
Dual specificity protein phosphatases inactivate their
target kinases by dephosphorylating both the
phosphoserine/threonine and phosphotyrosine residues. They
negatively regulate members of the MAPK superfamily (MAPK/ERK,
SAPK/JNK, p38), which is associated with cellular proliferation and
differentiation. Different members of this family of dual
specificity phosphatases show distinct substrate specificities for
MAPKs, different tissue distribution and subcellular localization,
and different modes of inducibility of their expression by
extracellular stimuli. This gene product binds to and inactivates
p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is
unique; it is evenly distributed in both the cytoplasm and the
nucleus. This gene is widely expressed in various tissues and
organs, and its expression is elevated by stress stimuli. Three
transcript variants encoding two different isoforms have been found
for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Tephly, L.A., et al. Am. J. Respir. Cell Mol. Biol. 39(1):113-123(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the Central region of human DUSP10.
NCBI Gene ID #:
11221
NCBI Official Name:
Dual specificity protein phosphatase 10
NCBI Official Symbol:
DUSP10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
Q9Y6W6
Protein GI Number:
20138090
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9Y6W6
User NOte:
Optimal dilutions for each application to be determined by the researcher.