PTPN22 Antibody
| Code | Size | Price |
|---|
| PSI-58-674-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP, PTPN22, PTPN8
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes of member of the non-receptor class 4
subfamily of the protein-tyrosine phosphatase family. The encoded
protein is a lymphoid-specific intracellular phosphatase that
associates with the molecular adapter protein CBL and may be
involved in regulating CBL function in the T-cell receptor
signaling pathway. Mutations in this gene may be associated with a
range of autoimmune disorders including Type 1 Diabetes, rheumatoid
arthritis, systemic lupus erythematosus and Graves' disease.
Alternatively spliced transcript variants encoding distinct
isoforms have been described.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Andersen, M.K., et al. Diabetes Care 33(9):2062-2064(2010)
- Bianco, B., et al. Scand. J. Immunol. 72(3):256-259(2010)
- Pradhan, V., et al.Postgrad Med 56(3):239-242(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PTPN22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-691 amino acids from the C-terminal region of human PTPN22.
NCBI Gene ID #:
26191
NCBI Official Name:
Tyrosine-protein phosphatase non-receptor type 22
NCBI Official Symbol:
PTPN22
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
92 kDa
Protein Accession #:
Q9Y2R2
Protein GI Number:
20139861
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9Y2R2
User NOte:
Optimal dilutions for each application to be determined by the researcher.