WAS Antibody
| Code | Size | Price |
|---|
| PSI-60-596-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2
Application Note:
For WB starting dilution is: 1:1000
Background:
The Wiskott-Aldrich syndrome (WAS) family of proteins
share similar domain structure, and are involved in transduction of
signals from receptors on the cell surface to the actin
cytoskeleton. The presence of a number of different motifs
suggests that they are regulated by a number of different stimuli,
and interact with multiple proteins. Recent studies have
demonstrated that these proteins, directly or indirectly, associate
with the small GTPase, Cdc42, known to regulate formation of actin
filaments, and the cytoskeletal organizing complex, Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive
disease characterized by immune dysregulation and
microthrombocytopenia, and is caused by mutations in the WAS gene.
The WAS gene product is a cytoplasmic protein, expressed
exclusively in hematopoietic cells, which show signalling and
cytoskeletal abnormalities in WAS patients. A transcript variant
arising as a result of alternative promoter usage, and containing a
different 5' UTR sequence, has been described, however, its
full-length nature is not known.
Background References:
- Burns, S.O., et al. Blood 115(26):5355-5365(2010)
- Taylor, M.D., et al. Sci Transl Med(37), 37RA44 (2010) :
- Rajmohan, R., et al. FEMS Yeast Res. 9(8):1226-1235(2009)
- Dovas, A., et al. J. Cell. Sci. 122 (PT 21), 3873-3882 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human WAS.
NCBI Gene ID #:
7454
NCBI Official Name:
Wiskott-Aldrich syndrome protein
NCBI Official Symbol:
WAS
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
P42768
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P42768
User NOte:
Optimal dilutions for each application to be determined by the researcher.