APPL2 Antibody

ProSci
Product Code: PSI-59-215
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-59-215-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis of APPL2 Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate.

Western blot analysis of APPL2 Antibody Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in NCI-H292 cell line lysate.

Further Information

Additional Names:
DCC-interacting protein 13-beta, Dip13-beta, Adapter protein containing PH domain, PTB domain and leucine zipper motif 2, APPL2, DIP13B
Application Note:
For WB starting dilution is: 1:1000
Background:
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Background References:
  • Chial, H.J., et al. PLoS ONE(8), E12471 (2010) :
  • Rashid, S., et al. J. Biol. Chem. 284(27):18115-18128(2009)
  • Chial, H.J., et al. Traffic 9(2):215-229(2008)
  • Nechamen, C.A., et al. Mol. Cell. Endocrinol. 260-262, 93-99 (2007) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This APPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human APPL2.
NCBI Gene ID #:
55198
NCBI Official Name:
DCC-interacting protein 13-beta
NCBI Official Symbol:
APPL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
74 kDa
Protein Accession #:
Q8NEU8
Protein GI Number:
160419148
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8NEU8
User NOte:
Optimal dilutions for each application to be determined by the researcher.