DHH Antibody
| Code | Size | Price |
|---|
| PSI-60-360-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Desert hedgehog protein, DHH, HHG-3, Desert hedgehog protein N-product, Desert hedgehog protein C-product, DHH
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the hedgehog family. The
hedgehog gene family encodes signaling molecules that play an
important role in regulating morphogenesis. This protein is
predicted to be made as a precursor that is autocatalytically
cleaved; the N-terminal portion is soluble and contains the
signalling activity while the C-terminal portion is involved in
precursor processing. More importantly, the C-terminal product
covalently attaches a cholesterol moiety to the N-terminal product,
restricting the N-terminal product to the cell surface and
preventing it from freely diffusing throughout the organism.
Defects in this protein have been associated with partial gonadal
dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This
protein may be involved in both male gonadal differentiation and
perineurial development.
Background References:
- Chinchilla, P., et al. Cell Cycle 9(3):570-579(2010)
- Bishop, B., et al. Nat. Struct. Mol. Biol. 16(7):698-703(2009)
- Hegde, G.V., et al. Mol. Cancer Res. 6(12):1928-1936(2008)
- Nakamura, M., et al. Fukuoka Igaku Zasshi 99(5):102-106(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This DHH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human DHH.
NCBI Gene ID #:
50846
NCBI Official Name:
Desert hedgehog protein
NCBI Official Symbol:
DHH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
O43323
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O43323
User NOte:
Optimal dilutions for each application to be determined by the researcher.