KDELR1 Antibody
| Code | Size | Price |
|---|
| PSI-60-332-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, KDEL receptor 1, Putative MAPK-activating protein PM23, KDELR1, ERD21
Application Note:
For WB starting dilution is: 1:2000
Background:
Retention of resident soluble proteins in the lumen of the
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, which
is a seven-transmembrane protein. Unlike yeast, several human
homologs of the ERD2 gene, constituting the KDEL receptor gene
family, have been described. The protein encoded by this gene was
the first member of the family to be identified, and it encodes a
protein structurally and functionally similar to the yeast ERD2
gene product.
Background References:
- Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
- Breuza, L., et al. J. Biol. Chem. 279(45):47242-47253(2004)
- Bard, F., et al. J. Biol. Chem. 278(47):46601-46606(2003)
- Yamamoto, K., et al. J. Biol. Chem. 278(36):34525-34532(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Zebrafish, Chicken, Xenopus, B
Immunogen:
This KDELR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1.
NCBI Gene ID #:
10945
NCBI Official Name:
ER lumen protein-retaining receptor 1
NCBI Official Symbol:
KDELR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
25 kDa
Protein Accession #:
P24390
Protein GI Number:
119543
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P24390
User NOte:
Optimal dilutions for each application to be determined by the researcher.