ARAP2 Antibody

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ProSci
Product Code: PSI-58-826
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-58-826-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H292 cell line lysates (35ug/lane).

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Further Information

Additional Names:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, Centaurin-delta-1, Cnt-d1, Protein PARX, ARAP2, CENTD1, KIAA0580
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.
Background References:
  • Gavicherla, B., et al. Infect. Immun. 78(11):4532-4541(2010)
  • Liu, C., et al. Mol. Med. 14 (9-10), 575-581 (2008) :
  • Yoon, H.Y., et al. J. Cell. Sci. 119 (PT 22), 4650-4666 (2006) :
  • Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ARAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 amino acids from the N-terminal region of human ARAP2.
NCBI Gene ID #:
116984
NCBI Official Name:
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
NCBI Official Symbol:
ARAP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
193 kDa
Protein Accession #:
Q8WZ64
Protein GI Number:
308153629
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8WZ64
User NOte:
Optimal dilutions for each application to be determined by the researcher.