IBSP Antibody
| Code | Size | Price |
|---|
| PSI-57-486-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Bone sialoprotein 2, Bone sialoprotein II, BSP II, Cell-binding sialoprotein, Integrin-binding sialoprotein, IBSP, BNSP
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a major structural
protein of the bone matrix. It constitutes approximately 12% of the
noncollagenous proteins in human bone and is synthesized by
skeletal-associated cell types, including hypertrophic
chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only
extraskeletal site of its synthesis is the trophoblast. This
protein binds to calcium and hydroxyapatite via its acidic amino
acid clusters, and mediates cell attachment through an RGD sequence
that recognizes the vitronectin receptor.
Background References:
- Giroux, S., et al. Bone 47(5):975-981(2010)
- Koller, D.L., et al. J. Clin. Endocrinol. Metab. 95(4):1802-1809(2010)
- Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
- Gordon, J.A., et al. J. Cell. Biochem. 107(6):1118-1128(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This IBSP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-99 amino acids from the N-terminal region of human IBSP.
NCBI Gene ID #:
3381
NCBI Official Name:
Bone sialoprotein 2
NCBI Official Symbol:
IBSP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
35 kDa
Protein Accession #:
P21815
Protein GI Number:
317373545
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P21815
User NOte:
Optimal dilutions for each application to be determined by the researcher.