GREM1 Antibody
| Code | Size | Price |
|---|
| PSI-56-300-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Gremlin-1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1, BMP antagonist 1, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, GREM1, CKTSF1B1, DAND2, DRM
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the BMP (bone morphogenic
protein) antagonist family. Like BMPs, BMP antagonists contain
cystine knots and typically form homo- and heterodimers. The CAN
(cerberus and dan) subfamily of BMP antagonists, to which this gene
belongs, is characterized by a C-terminal cystine knot with an
eight-membered ring. The antagonistic effect of the secreted
glycosylated protein encoded by this gene is likely due to its
direct binding to BMP proteins. As an antagonist of BMP, this gene
may play a role in regulating organogenesis, body patterning, and
tissue differentiation. In mouse, this protein has been shown to
relay the sonic hedgehog (SHH) signal from the polarizing region to
the apical ectodermal ridge during limb bud outgrowth.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.
Background References:
- Kupfer, S.S., et al. Gastroenterology 139(5):1677-1685(2010)
- Dimitrov, B.I., et al. J. Med. Genet. 47(8):569-574(2010)
- McKnight, A.J., et al. J. Am. Soc. Nephrol. 21(5):773-781(2010)
- van Vlodrop, I.J., et al. Am. J. Pathol. 176(2):575-584(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This GREM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the C-terminal region of human GREM1.
NCBI Gene ID #:
26585
NCBI Official Name:
Gremlin-1
NCBI Official Symbol:
GREM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
Protein Accession #:
O60565
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O60565
User NOte:
Optimal dilutions for each application to be determined by the researcher.