PEX19 Antibody
| Code | Size | Price |
|---|
| PSI-57-701-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Peroxisomal biogenesis factor 19, 33 kDa housekeeping protein, Peroxin-19, Peroxisomal farnesylated protein, PEX19, HK33, PXF
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is necessary for early peroxisomal biogenesis.
It acts both as a cytosolic chaperone and as an import receptor for
peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins
that are essential for the assembly of functional peroxisomes. The
peroxisome biogenesis disorders (PBDs) are a group of genetically
heterogeneous autosomal recessive, lethal diseases characterized by
multiple defects in peroxisome function. These disorders have at
least 14 complementation groups, with more than one phenotype being
observed for some complementation groups. Although the clinical
features of PBD patients vary, cells from all PBD patients exhibit
a defect in the import of one or more classes of peroxisomal matrix
proteins into the organelle. Defects in this gene are a cause of
Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder
complementation group 14 (PBD-CG14), which is also known as
PBD-CGJ. Alternative splicing results in multiple transcript
variants.
Background References:
- Mohamed, S., et al. Am. J. Med. Genet.152A (9), 2318-2321 (2010) :
- Schmidt, F., et al. J. Biol. Chem. 285(33):25410-25417(2010)
- Schueller, N., et al. EMBO J. 29(15):2491-2500(2010)
- Liu, Y., et al.Psychiatr Res (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rat
Immunogen:
This PEX19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human PEX19.
NCBI Gene ID #:
5824
NCBI Official Name:
Peroxisomal biogenesis factor 19
NCBI Official Symbol:
PEX19
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
33 kDa
Protein Accession #:
P40855
Protein GI Number:
729723
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P40855
User NOte:
Optimal dilutions for each application to be determined by the researcher.