PTPN18 Antibody
| Code | Size | Price |
|---|
| PSI-58-809-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Tyrosine-protein phosphatase non-receptor type 18, Brain-derived phosphatase, PTPN18, BDP1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, the mitotic cycle, and
oncogenic transformation. This PTP contains a PEST motif, which
often serves as a protein-protein interaction domain, and may be
related to protein intracellular half-live. This protein can
differentially dephosphorylate autophosphorylated tyrosine kinases
that are overexpressed in tumor tissues, and it appears to regulate
HER2, a member of the epidermal growth factor receptor family of
receptor tyrosine kinases. Two transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Background References:
- Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
- Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)
- Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
- Blanchetot, C., et al. Methods 35(1):44-53(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This PTPN18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-459 amino acids from the C-terminal region of human PTPN18.
NCBI Gene ID #:
26469
NCBI Official Name:
Tyrosine-protein phosphatase non-receptor type 18
NCBI Official Symbol:
PTPN18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q99952
Protein GI Number:
215273871
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q99952
User NOte:
Optimal dilutions for each application to be determined by the researcher.