SOCS7 Antibody
| Code | Size | Price |
|---|
| PSI-58-953-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, NAP-4, SOCS7, NAP4, SOCS6
Application Note:
For WB starting dilution is: 1:1000
Background:
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Background References:
- Pazienza, V., et al. J. Gen. Virol. 91 (PT 7), 1678-1686 (2010) :
- Sasi, W., et al. BMC Cancer 10, 178 (2010) :
- Kremer, B.E., et al. Cell 130(5):837-850(2007)
- Zody, M.C., et al. Nature 440(7087):1045-1049(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7.
NCBI Gene ID #:
30837
NCBI Official Name:
Suppressor of cytokine signaling 7
NCBI Official Symbol:
SOCS7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
63 kDa
Protein Accession #:
O14512
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O14512
User NOte:
Optimal dilutions for each application to be determined by the researcher.