IPO11 Antibody
| Code | Size | Price |
|---|
| PSI-64-054-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Importin-11, Imp11, Ran-binding protein 11, RanBP11, IPO11, RANBP11
Application Note:
For WB starting dilution is: 1:1000
Background:
IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).
Background References:
- Plafker,S.M. et.al., Mol. Cell. Biol. 22 (4), 1266-1275 (2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This IPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 891-920 amino acids from the C-terminal region of human IPO11.
NCBI Gene ID #:
51194
NCBI Official Name:
Importin-11
NCBI Official Symbol:
IPO11
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
Q9UI26
Protein GI Number:
50401199
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9UI26
User NOte:
Optimal dilutions for each application to be determined by the researcher.