FBLN5 Antibody
| Code | Size | Price |
|---|
| PSI-59-590-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Fibulin-5, FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50, FBLN5, DANCE
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a secreted,
extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif
and calcium-binding EGF-like domains. It promotes adhesion of
endothelial cells through interaction of integrins and the RGD
motif. It is prominently expressed in developing arteries but less
so in adult vessels. However, its expression is reinduced in
balloon-injured vessels and atherosclerotic lesions, notably in
intimal vascular smooth muscle cells and endothelial cells.
Therefore, the protein encoded by this gene may play a role in
vascular development and remodeling. Defects in this gene are a
cause of autosomal dominant cutis laxa, autosomal recessive cutis
laxa type I (CL type I), and age-related macular degeneration type
3 (ARMD3).
Background References:
- Schneider, R., et al. J. Mol. Biol. 401(4):605-617(2010)
- Zhou, S., et al. Biochem. Biophys. Res. Commun. 398(2):247-253(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FBLN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 393-421 amino acids from the C-terminal region of human FBLN5.
NCBI Gene ID #:
10516
NCBI Official Name:
Fibulin-5
NCBI Official Symbol:
FBLN5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q9UBX5
Protein GI Number:
12643876
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9UBX5
User NOte:
Optimal dilutions for each application to be determined by the researcher.