UNC84B Antibody
| Code | Size | Price |
|---|
| PSI-56-427-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
SUN domain-containing protein 2, Protein unc-84 homolog B, Rab5-interacting protein, Rab5IP, Sad1/unc-84 protein-like 2, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B
Application Note:
For WB starting dilution is: 1:1000
Background:
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane
(INM) proteins that play a major role in nuclear-cytoplasmic
connection by formation of a 'bridge' across the nuclear envelope,
known as the LINC complex, via interaction with the conserved
luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located
in the outer nuclear membrane (ONM). The LINC complex provides a
direct connection between the nuclear lamina and the cytoskeleton,
which contributes to nuclear positioning and cellular rigidity
(summary by Haque et al., 2010 [PubMed 19933576]).[supplied by
OMIM].
Background References:
- Turgay, Y., et al. EMBO J. 29(14):2262-2275(2010)
- Haque, F., et al. J. Biol. Chem. 285(5):3487-3498(2010)
- Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314(8):1892-1905(2008)
- Cerhan, J.R., et al. Blood 110(13):4455-4463(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UNC84B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-265 amino acids from the Central region of human UNC84B.
NCBI Gene ID #:
25777
NCBI Official Name:
SUN domain-containing protein 2
NCBI Official Symbol:
SUN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
80 kDa
Protein Accession #:
Q9UH99
Protein GI Number:
29337242
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9UH99
User NOte:
Optimal dilutions for each application to be determined by the researcher.