NR3C2 Antibody
| Code | Size | Price |
|---|
| PSI-59-019-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2, NR3C2, MCR, MLR
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the mineralocorticoid receptor, which
mediates aldosterone actions on salt and water balance within
restricted target cells. The protein functions as a
ligand-dependent transcription factor that binds to
mineralocorticoid response elements in order to transactivate
target genes. Mutations in this gene cause autosomal dominant
pseudohypoaldosteronism type I, a disorder characterized by urinary
salt wasting. Defects in this gene are also associated with early
onset hypertension with severe exacerbation in pregnancy.
Alternative splicing results in multiple transcript variants.
Background References:
- van Leeuwen, N., et al. Hypertension 56(5):995-1002(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Bouma, E.M., et al. Behav. Genet. (2010) In press :
- Bogdan, R., et al. Genes Brain Behav. 9(6):658-667(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat, Xenopus
Immunogen:
This NR3C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-683 amino acids from the Central region of human NR3C2.
NCBI Gene ID #:
4306
NCBI Official Name:
Mineralocorticoid receptor
NCBI Official Symbol:
NR3C2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
107 kDa
Protein Accession #:
P08235
Protein GI Number:
126885
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P08235
User NOte:
Optimal dilutions for each application to be determined by the researcher.