RGS14 Antibody
| Code | Size | Price |
|---|
| PSI-58-653-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Regulator of G-protein signaling 14, RGS14, RGS14
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the regulator of G-protein
signaling family. This protein contains one RGS domain, two
Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The
protein attenuates the signaling activity of G-proteins by binding,
through its GoLoco domain, to specific types of activated,
GTP-bound G alpha subunits. Acting as a GTPase activating protein
(GAP), the protein increases the rate of conversion of the GTP to
GDP. This hydrolysis allows the G alpha subunits to bind G
beta/gamma subunit heterodimers, forming inactive G-protein
heterotrimers, thereby terminating the signal. Alternate
transcriptional splice variants of this gene have been observed but
have not been thoroughly characterized.
Background References:
- Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
- Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
- Shu, F.J., et al. Cell. Signal. 22(3):366-376(2010)
- Dowler, E.F., et al. Biomol NMR Assign 1(1):95-97(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RGS14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the Central region of human RGS14.
NCBI Gene ID #:
10636
NCBI Official Name:
Regulator of G-protein signaling 14
NCBI Official Symbol:
RGS14
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
61 kDa
Protein Accession #:
O43566
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O43566
User NOte:
Optimal dilutions for each application to be determined by the researcher.