UPK1A Antibody
| Code | Size | Price |
|---|
| PSI-63-846-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Uroplakin-1a, UP1a, Tetraspanin-21, Tspan-21, Uroplakin Ia, UPIa, UPKa, UPK1A, TSPAN21
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Background References:
- Wang,H., et.al., J. Mol. Biol. 392 (2), 352-361 (2009)
- Hall,G.D., et.al., Biochim. Biophys. Acta 1729 (2), 126-134 (2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This UPK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-217 amino acids from the C-terminal region of human UPK1A.
NCBI Gene ID #:
11045
NCBI Official Name:
Uroplakin-1a
NCBI Official Symbol:
UPK1A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
29 kDa
Protein Accession #:
O00322
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O00322
User NOte:
Optimal dilutions for each application to be determined by the researcher.