PDZD3 Antibody
| Code | Size | Price |
|---|
| PSI-59-347-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2
Application Note:
For WB starting dilution is: 1:1000
Background:
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces
cGMP following the binding of either endogenous ligands or
heat-stable enterotoxins secreted by E. coli and other enteric
bacteria. Activation of GCC initiates a signaling cascade that
leads to phosphorylation of the cystic fibrosis transmembrane
conductance regulator (CFTR; MIM 602421), followed by a net efflux
of ions and water into the intestinal lumen. IKEPP is a regulatory
protein that associates with GCC and regulates the amount of cGMP
produced following receptor stimulation (Scott et al., 2002 [PubMed
11950846]).
Background References:
- Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) :
- Kato, Y., et al. Mol. Pharmacol. 67(3):734-743(2005)
- Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302(3):454-461(2003)
- Scott, R.O., et al. J. Biol. Chem. 277(25):22934-22941(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.
NCBI Gene ID #:
79849
NCBI Official Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
NCBI Official Symbol:
PDZD3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
61 kDa
Protein Accession #:
Q86UT5
Protein GI Number:
308153467
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q86UT5
User NOte:
Optimal dilutions for each application to be determined by the researcher.