KRT86 Antibody
| Code | Size | Price |
|---|
| PSI-60-876-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Keratin, type II cuticular Hb6, Hair keratin K211, Keratin-86, K86, Type II hair keratin Hb6, Type-II keratin Kb26, KRT86, KRTHB6
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the
keratin gene family. As a type II hair keratin, it is a basic
protein which heterodimerizes with type I keratins to form hair and
nails. The type II hair keratins are clustered in a region of
chromosome 12q13 and are grouped into two distinct subfamilies
based on structure similarity. One subfamily, consisting of KRTHB1,
KRTHB3, and KRTHB6, is highly related. The other less-related
subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins
are expressed in the hair follicle; this hair keratin, as well as
KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations
in this gene and KRTHB1 have been observed in patients with a rare
dominant hair disease, monilethrix.
Background References:
- ZHANG, S.D., et al. EurDermatol 19(5):508-509(2009)
- Feng, A.P., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25(2):141-144(2008)
- Lamesch, P., et al. Genomics 89(3):307-315(2007)
- Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86.
NCBI Gene ID #:
3892
NCBI Official Name:
Keratin, type II cuticular Hb6
NCBI Official Symbol:
KRT86
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
O43790
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O43790
User NOte:
Optimal dilutions for each application to be determined by the researcher.