HBG1 Antibody
| Code | Size | Price |
|---|
| PSI-57-207-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1
Application Note:
For WB starting dilution is: 1:1000
Background:
The gamma globin genes (HBG1 and HBG2) are normally
expressed in the fetal liver, spleen and bone marrow. Two gamma
chains together with two alpha chains constitute fetal hemoglobin
(HbF) which is normally replaced by adult hemoglobin (HbA) at
birth. In some beta-thalassemias and related conditions, gamma
chain production continues into adulthood. The two types of gamma
chains differ at residue 136 where glycine is found in the G-gamma
product (HBG2) and alanine is found in the A-gamma product (HBG1).
The former is predominant at birth. The order of the genes in the
beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta
-- beta--3'.
Background References:
- Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)
- Miccio, A., et al. Mol. Cell. Biol. 30(14):3460-3470(2010)
- Nuinoon, M., et al. Hum. Genet. (2009) In press :
- da Cunha, A.F., et al. Hemoglobin 33(6):439-447(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human HBG1.
NCBI Gene ID #:
3047
NCBI Official Name:
Hemoglobin subunit gamma-1
NCBI Official Symbol:
HBG1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
16 kDa
Protein Accession #:
P69891
Protein GI Number:
56749860
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P69891
User NOte:
Optimal dilutions for each application to be determined by the researcher.