MAP4K2 Antibody
| Code | Size | Price |
|---|
| PSI-56-360-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Mitogen-activated protein kinase kinase kinase kinase 2, B lymphocyte serine/threonine-protein kinase, Germinal center kinase, GC kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, MEKKK 2, Rab8-interacting protein, MAP4K2, GCK, RAB8IP
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the
serine/threonine protein kinase family. Although this kinase is
found in many tissues, its expression in lymphoid follicles is
restricted to the cells of germinal centre, where it may
participate in B-cell differentiation. This kinase can be activated
by TNF-alpha, and has been shown to specifically activate MAP
kinases. This kinase is also found to interact with TNF
receptor-associated factor 2 (TRAF2), which is involved in the
activation of MAP3K1/MEKK1.
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Fidalgo, M., et al. J. Cell. Sci. 123 (PT 8), 1274-1284 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Wissing, J., et al. Mol. Cell Proteomics 6(3):537-547(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This MAP4K2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-349 amino acids from the Central region of human MAP4K2.
NCBI Gene ID #:
5871
NCBI Official Name:
Mitogen-activated protein kinase kinase kinase kinase 2
NCBI Official Symbol:
MAP4K2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
92 kDa
Protein Accession #:
Q12851
Protein GI Number:
215274019
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q12851
User NOte:
Optimal dilutions for each application to be determined by the researcher.