PDE4B Antibody
| Code | Size | Price |
|---|
| PSI-55-986-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B, DPDE4, PDE32, PDE4B, DPDE4
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
This gene is a member of the type IV, cyclic AMP
(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.
Cyclic nucleotides are important second messengers that regulate
and mediate a number of cellular responses to extracellular
signals, such as hormones, light, and neurotransmitters. The cyclic
nucleotide phosphodiesterases (PDEs) regulate the cellular
concentrations of cyclic nucleotides and thereby play a role in
signal transduction. This gene encodes a protein that specifically
hydrolyzes cAMP. Altered activity of this protein has been
associated with schizophrenia and bipolar affective disorder.
Alternate transcriptional splice variants, encoding different
isoforms, have been characterized.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Souza, R.P., et al. Int Clin Psychopharmacol 25(5):264-269(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PDE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-217 amino acids from the Central region of human PDE4B.
NCBI Gene ID #:
5142
NCBI Official Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
NCBI Official Symbol:
PDE4B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
83 kDa
Protein Accession #:
Q07343
Protein GI Number:
729163
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q07343
User NOte:
Optimal dilutions for each application to be determined by the researcher.