SOCS6 Antibody
| Code | Size | Price |
|---|
| PSI-57-489-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, CIS-4, Suppressor of cytokine signaling 4, SOCS-4, SOCS6, CIS4, SOCS4
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene contains a SH2 domain and
a CIS homolog domain. The protein thus belongs to the
cytokine-induced STAT inhibitor (CIS), also known as suppressor of
cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI),
protein family. CIS family members are known to be
cytokine-inducible negative regulators of cytokine signaling. The
expression of this gene can be induced by GM-CSF and EPO in
hematopoietic cells. A high expression level of this gene was found
in factor-independent chronic myelogenous leukemia (CML) and
erythroleukemia (HEL) cell lines.
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Choi, Y.B., et al. J. Biol. Chem. 285(10):7271-7280(2010)
- Lai, R.H., et al. Gene 448(1):64-73(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SOCS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SOCS6.
NCBI Gene ID #:
9306
NCBI Official Name:
Suppressor of cytokine signaling 6
NCBI Official Symbol:
SOCS6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
O14544
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O14544
User NOte:
Optimal dilutions for each application to be determined by the researcher.