HDAC7 Antibody
Code | Size | Price |
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PSI-57-176-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Histone deacetylase 7, HD7, Histone deacetylase 7A, HD7a, HDAC7, HDAC7A
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Histones play a critical role in transcriptional
regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and
affects transcription factor access to DNA. The protein encoded by
this gene has sequence homology to members of the histone
deacetylase family. This gene is orthologous to mouse HDAC7 gene
whose protein promotes repression mediated via the transcriptional
corepressor SMRT. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Margariti, A., et al. Circ. Res. 106(7):1202-1211(2010)
- Hutt, D.M., et al. Nat. Chem. Biol. 6(1):25-33(2010)
- Malik, S., et al. Mol. Cell. Biol. 30(2):399-412(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HDAC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-875 amino acids from the C-terminal region of human HDAC7.
NCBI Gene ID #:
51564
NCBI Official Name:
Histone deacetylase 7
NCBI Official Symbol:
HDAC7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
103 kDa
Protein Accession #:
Q8WUI4
Protein GI Number:
30913097
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8WUI4
User NOte:
Optimal dilutions for each application to be determined by the researcher.