FXYD5 Antibody
| Code | Size | Price |
|---|
| PSI-58-089-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, DYSAD, IWU1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a member of a family of small membrane
proteins that share a 35-amino acid signature sequence domain,
beginning with the sequence PFXYD and containing 7 invariant and 6
highly conserved amino acids. The approved human gene nomenclature
for the family is FXYD-domain containing ion transport regulator.
Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
also known as the gamma subunit of the Na,K-ATPase, regulates the
properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
induce channel activity in experimental expression systems.
Transmembrane topology has been established for two family members
(FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. This gene
product, FXYD5, is a glycoprotein that functions in the
up-regulation of chemokine production, and it is involved in the
reduction of cell adhesion via its ability to down-regulate
E-cadherin. It also promotes metastasis, and has been linked to a
variety of cancers. Alternative splicing results in multiple
transcript variants. [RefSeq curation by Kathleen J. Sweadner,
Ph.D., sweadner@helix.mgh.harvard.edu.].
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Ono, K., et al. Anticancer Res. 30(9):3273-3278(2010)
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Liang, J.F., et al. Pathol. Res. Pract. 205(7):445-450(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FXYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human FXYD5.
NCBI Gene ID #:
53827
NCBI Official Name:
FXYD domain-containing ion transport regulator 5
NCBI Official Symbol:
FXYD5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
19 kDa
Protein Accession #:
Q96DB9
Protein GI Number:
311033386
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q96DB9
User NOte:
Optimal dilutions for each application to be determined by the researcher.