VASP Antibody
| Code | Size | Price |
|---|
| PSI-57-408-400ul | 400ul | £662.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Vasodilator-stimulated phosphoprotein, VASP, VASP
Application Note:
For WB starting dilution is: 1:2000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Vasodilator-stimulated phosphoprotein (VASP) is a member
of the Ena-VASP protein family. Ena-VASP family members contain an
EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E
motifs and targets Ena-VASP proteins to focal adhesions. In the
mid-region of the protein, family members have a proline-rich
domain that binds SH3 and WW domain-containing proteins. Their
C-terminal EVH2 domain mediates tetramerization and binds both G
and F actin. VASP is associated with filamentous actin formation
and likely plays a widespread role in cell adhesion and motility.
VASP may also be involved in the intracellular signaling pathways
that regulate integrin-extracellular matrix interactions. VASP is
regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Background References:
- Barragan, P., et al. Thromb. Haemost. 104(2):410-411(2010)
- Dittrich, M., et al. Arterioscler. Thromb. Vasc. Biol. 30(4):843-850(2010)
- Gan, L., et al. Mol. Immunol. 47(6):1278-1282(2010)
- Osmancik, P., et al. Catheter Cardiovasc Interv 75(2):158-166(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This VASP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human VASP.
NCBI Gene ID #:
7408
NCBI Official Name:
Vasodilator-stimulated phosphoprotein
NCBI Official Symbol:
VASP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 kDa
Protein Accession #:
P50552
Protein GI Number:
1718079
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P50552
User NOte:
Optimal dilutions for each application to be determined by the researcher.