BMPR1B Antibody
| Code | Size | Price |
|---|
| PSI-56-190-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, CDw293, BMPR1B
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a member of the bone morphogenetic
protein (BMP) receptor family of transmembrane serine/threonine
kinases. The ligands of this receptor are BMPs, which are members
of the TGF-beta superfamily. BMPs are involved in endochondral bone
formation and embryogenesis. These proteins transduce their signals
through the formation of heteromeric complexes of 2 different types
of serine (threonine) kinase receptors: type I receptors of about
50-55 kD and type II receptors of about 70-80 kD. Type II receptors
bind ligands in the absence of type I receptors, but they require
their respective type I receptors for signaling, whereas type I
receptors require their respective type II receptors for ligand
binding. Mutations in this gene have been associated with primary
pulmonary hypertension.
Background References:
- Mick, E., et al.Am Acad Child Adolesc Psychiatry 49(9):898-905(2010)
- Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Ma, Y., et al. J. Exp. Clin. Cancer Res. 29, 85 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-162 amino acids from the Central region of human BMPR1B.
NCBI Gene ID #:
658
NCBI Official Name:
Bone morphogenetic protein receptor type-1B
NCBI Official Symbol:
BMPR1B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
O00238
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
O00238
User NOte:
Optimal dilutions for each application to be determined by the researcher.