ARHGDIB Antibody
| Code | Size | Price |
|---|
| PSI-57-239-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rho GDP-dissociation inhibitor 2, Rho GDI 2, Ly-GDI, Rho-GDI beta, ARHGDIB, GDIA2, GDID4, RAP1GN1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Members of the Rho (or ARH) protein family (see MIM
165390) and other Ras-related small GTP-binding proteins (see MIM
179520) are involved in diverse cellular events, including cell
signaling, proliferation, cytoskeletal organization, and secretion.
The GTP-binding proteins are active only in the GTP-bound state. At
least 3 classes of proteins tightly regulate cycling between the
GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs),
guanine nucleotide-releasing factors (GRFs), and GDP-dissociation
inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate
of GDP dissociation from Ras-like GTPases (summary by Scherle et
al., 1993 [PubMed 8356058]).
Background References:
- Niu, H., et al. Oncol. Rep. 24(2):465-471(2010)
- Zhen, H., et al. Int. J. Gynecol. Cancer 20(3):316-322(2010)
- Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
- Said, N., et al. Cancer Metastasis Rev. 28 (3-4), 327-333 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This ARHGDIB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human ARHGDIB.
NCBI Gene ID #:
397
NCBI Official Name:
Rho GDP-dissociation inhibitor 2
NCBI Official Symbol:
ARHGDIB
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
Protein Accession #:
P52566
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P52566
User NOte:
Optimal dilutions for each application to be determined by the researcher.