TMEM43 Antibody
| Code | Size | Price |
|---|
| PSI-56-541-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Transmembrane protein 43, Protein LUMA, TMEM43
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene belongs to the TMEM43 family. Defects in this
gene are the cause of familial arrhythmogenic right ventricular
dysplasia type 5 (ARVD5), also known as arrhythmogenic right
ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right
ventricular dysplasia is an inherited disorder, often involving
both ventricles, and is characterized by ventricular tachycardia,
heart failure, sudden cardiac death, and fibrofatty replacement of
cardiomyocytes. This gene contains a response element for PPAR
gamma (an adipogenic transcription factor), which may explain the
fibrofatty replacement of the myocardium, a characteristic
pathological finding in ARVC.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Barahona-Dussault, C., et al. Clin. Genet. 77(1):37-48(2010)
- Hodgkinson, K., et al. Genet. Med. 11(12):859-865(2009)
- Merner, N.D., et al. Am. J. Hum. Genet. 82(4):809-821(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
NCBI Gene ID #:
79188
NCBI Official Name:
Transmembrane protein 43
NCBI Official Symbol:
TMEM43
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
Q9BTV4
Protein GI Number:
74733151
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q9BTV4
User NOte:
Optimal dilutions for each application to be determined by the researcher.