DSG1 Antibody
| Code | Size | Price |
|---|
| PSI-57-728-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Desmosomes are cell-cell junctions between epithelial,
myocardial and certain other cell types. Desmoglein 1 is a
calcium-binding transmembrane glycoprotein component of desmosomes
in vertebrate epithelial cells. Currently, three desmoglein
subfamily members have been identified and all are members of the
cadherin cell adhesion molecule superfamily. These desmoglein gene
family members are located in a cluster on chromosome 18. The
protein encoded by this gene has been identified as the autoantigen
of the autoimmune skin blistering disease pemphigus foliaceus.
Background References:
- Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)
- Naoe, Y., et al. J. Dermatol. Sci. 57(3):192-198(2010)
- Qian, Y., et al. J. Invest. Dermatol. 129(12):2823-2834(2009)
- Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1.
NCBI Gene ID #:
1828
NCBI Official Name:
Desmoglein-1
NCBI Official Symbol:
DSG1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
114 kDa
Protein Accession #:
Q02413
Protein GI Number:
292495005
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q02413
User NOte:
Optimal dilutions for each application to be determined by the researcher.