STAT2 Antibody
| Code | Size | Price |
|---|
| PSI-57-243-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Signal transducer and activator of transcription 2, p113, STAT2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene is a member of the STAT
protein family. In response to cytokines and growth factors, STAT
family members are phosphorylated by the receptor associated
kinases, and then form homo- or heterodimers that translocate to
the cell nucleus where they act as transcription activators. In
response to interferon (IFN), this protein forms a complex with
STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in
which this protein acts as a transactivator, but lacks the ability
to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP)
has been shown to interact specifically with this protein, which is
thought to be involved in the process of blocking IFN-alpha
response by adenovirus. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Background References:
- Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
- Lou, Y.J., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27(3):255-258(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig
Immunogen:
This STAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-215 amino acids from the N-terminal region of human STAT2.
NCBI Gene ID #:
6773
NCBI Official Name:
Signal transducer and activator of transcription 2
NCBI Official Symbol:
STAT2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
98 kDa
Protein Accession #:
P52630
Protein GI Number:
1711552
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P52630
User NOte:
Optimal dilutions for each application to be determined by the researcher.