MARK3 Antibody
| Code | Size | Price |
|---|
| PSI-62-742-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
MAP/microtubule affinity-regulating kinase 3, C-TAK1, cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, MARK3, CTAK1, EMK2
Application Note:
For IHC-P starting dilution is: 1:50~100
For WB starting dilution is: 1:1000
For WB starting dilution is: 1:1000
Background:
MARK proteins are involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2, and MAP4. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK3 may be involved in cell cycle regulation, and alterations in the MARK3 gene may lead to carcinogenesis.
Background References:
- Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
- Sun, T.Q., et al., Nat. Cell Biol. 3(7):628-636 (2001).
- Peng, C.Y., et al., Cell Growth Differ. 9(3):197-208 (1998).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This MARK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 570-601 amino acids from the C-terminal region of human MARK3.
NCBI Gene ID #:
4140
NCBI Official Name:
MAP/microtubule affinity-regulating kinase 3
NCBI Official Symbol:
MARK3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
84 kDa
Protein Accession #:
P27448
Protein GI Number:
341941142
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P27448
User NOte:
Optimal dilutions for each application to be determined by the researcher.