KDELR2 Antibody
| Code | Size | Price |
|---|
| PSI-57-940-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
ER lumen protein-retaining receptor 2, ERD2-like protein 1, ELP-1, KDEL endoplasmic reticulum protein retention receptor 2, KDEL receptor 2, KDELR2, ERD22
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Retention of resident soluble proteins in the lumen of the
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, is a
seven-transmembrane protein. Unlike yeast, several human homologs
of the ERD2 gene, constituting the KDEL receptor gene family, have
been described. KDELR2 was the second member of the family to be
identified, and it encodes a protein which is 83% identical to the
KDELR1 gene product. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq].
Background References:
- van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :
- Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)
- Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)
- Hsu, V.W., et al. Cell 69(4):625-635(1992)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Mouse, Rat
Immunogen:
This KDELR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2.
NCBI Gene ID #:
11014
NCBI Official Name:
ER lumen protein-retaining receptor 2
NCBI Official Symbol:
KDELR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
P33947
Protein GI Number:
462018
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P33947
User NOte:
Optimal dilutions for each application to be determined by the researcher.