FBLIM1 Antibody
| Code | Size | Price |
|---|
| PSI-56-601-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Filamin-binding LIM protein 1, FBLP-1, Migfilin, Mitogen-inducible 2-interacting protein, MIG2-interacting protein, FBLIM1, FBLP1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a protein with an N-terminal
filamin-binding domain, a central proline-rich domain, and,
multiple C-terminal LIM domains. This protein localizes at cell
junctions and may link cell adhesion structures to the actin
cytoskeleton. This protein may be involved in the assembly and
stabilization of actin-filaments and likely plays a role in
modulating cell adhesion, cell morphology and cell motility. This
protein also localizes to the nucleus and may affect cardiomyocyte
differentiation after binding with the CSX/NKX2-5 transcription
factor. Alternative splicing results in multiple transcript
variants encoding different isoforms.
Background References:
- Zhao, J., et al. J. Biol. Chem. 284(49):34308-34320(2009)
- Ithychanda, S.S., et al. J. Biol. Chem. 284(7):4713-4722(2009)
- Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)
- Lai-Cheong, J.E., et al. J. Invest. Dermatol. 128(9):2156-2165(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FBLIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the C-terminal region of human FBLIM1.
NCBI Gene ID #:
54751
NCBI Official Name:
Filamin-binding LIM protein 1
NCBI Official Symbol:
FBLIM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
41 kDa
Protein Accession #:
Q8WUP2
Protein GI Number:
125987829
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
Q8WUP2
User NOte:
Optimal dilutions for each application to be determined by the researcher.