INPP5B Antibody
| Code | Size | Price |
|---|
| PSI-55-215-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Type II inositol 1,5-trisphosphate 5-phosphatase, 75 kDa inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase, 5PTase, INPP5B, OCRL2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
Cellular calcium signaling is controlled by the production
of inositol phosphates (IPs) by phospholipase C in response to
extracellular signals. The IP signaling molecules are inactivated
by a family of inositol polyphosphate-5-phosphatases
(5-phosphatases). INPP5B encodes the type II 5-phosphatase. The
protein is localized to the cytosol and mitochondria, and
associates with membranes through an isoprenyl modification near
the C-terminus. Several alternatively spliced transcript variants
of this gene have been described, but the full-length nature of
some of these variants has not been determined. [provided by
RefSeq].
Background References:
- Coon, B.G., et al. Hum. Mol. Genet. 18(23):4478-4491(2009)
- Mao, Y., et al. EMBO J. 28(13):1831-1842(2009)
- Williams, C., et al. J. Cell. Sci. 120 (PT 22), 3941-3951 (2007) :
- Speed, C.J., et al. Eur. J. Biochem. 234(1):216-224(1995)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 950-979 amino acids from the C-terminal region of human INPP5B.
NCBI Gene ID #:
3633
NCBI Official Name:
Type II inositol 1,4,5-trisphosphate 5-phosphatase
NCBI Official Symbol:
INPP5B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
113 kDa
Protein Accession #:
P32019
Protein GI Number:
281185510
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction
Swissprot #:
P32019
User NOte:
Optimal dilutions for each application to be determined by the researcher.