TRHR Antibody
| Code | Size | Price |
|---|
| PSI-59-858-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, TRHR
Application Note:
For WB starting dilution is: 1:1000
Background:
Thyrotropin-releasing hormone (TRH; MIM 275120), a small
neuropeptide, is widely distributed throughout the central and
peripheral nervous system as well as in extraneural tissues. The
peptide is synthesized in the hypothalamus and transported by the
portal vascular system to the anterior pituitary where it acts on
thyrotropic and lactotropic cells to promote secretion of TSH and
prolactin, respectively. Thyrotropin-releasing hormone receptor is
a G protein-coupled receptor that activates the inositol
phospholipid-calcium-protein kinase C transduction pathway upon the
binding of TRH. The TRHR gene is expressed in the thyrotrope cells
of the anterior pituitary.
Background References:
- Gehret, A.U., et al. Biochem. J. 428(2):235-245(2010)
- Gehret, A.U., et al. Mol. Pharmacol. 77(2):288-297(2010)
- Zhu, C.C., et al. J. Biol. Chem. 277(31):28228-28237(2002)
- Matre, V., et al. J. Neurochem. 72(1):40-50(1999)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This TRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 amino acids from the Central region of human TRHR.
NCBI Gene ID #:
7201
NCBI Official Name:
Thyrotropin-releasing hormone receptor
NCBI Official Symbol:
TRHR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
P34981
Protein GI Number:
464921
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction,Growth Factor
Swissprot #:
P34981
User NOte:
Optimal dilutions for each application to be determined by the researcher.