FZD6 Antibody
| Code | Size | Price |
|---|
| PSI-55-557-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Frizzled-6, Fz-6, hFz6, FZD6
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene represents a member of the 'frizzled' gene
family, which encode 7-transmembrane domain proteins that are
receptors for Wnt signaling proteins. The protein encoded by this
family member contains a signal peptide, a cysteine-rich domain in
the N-terminal extracellular region, and seven transmembrane
domains, but unlike other family members, this protein does not
contain a C-terminal PDZ domain-binding motif. This protein
functions as a negative regulator of the canonical Wnt/beta-catenin
signaling cascade, thereby inhibiting the processes that trigger
oncogenic transformation, cell proliferation, and inhibition of
apoptosis. Alternative splicing results in multiple transcript
variants.
Background References:
- Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
- Kim, J.G., et al. J. Korean Med. Sci. 24(3):443-447(2009)
- Miyakoshi, T., et al. Endocr. Pathol. 19(4):261-273(2008)
- Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6.
NCBI Gene ID #:
8323
NCBI Official Name:
Frizzled-6
NCBI Official Symbol:
FZD6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
79 kDa
Protein Accession #:
O60353
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Signal Transduction,Growth Factor
Swissprot #:
O60353
User NOte:
Optimal dilutions for each application to be determined by the researcher.