DNMT3A Antibody
| Code | Size | Price |
|---|
| PSI-58-155-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, MHsaIIIA, DNMT3A
Application Note:
For WB starting dilution is: 1:1000
Background:
CpG methylation is an epigenetic modification that is
important for embryonic development, imprinting, and X-chromosome
inactivation. Studies in mice have demonstrated that DNA
methylation is required for mammalian development. This gene
encodes a DNA methyltransferase that is thought to function in de
novo methylation, rather than maintenance methylation. The protein
localizes to the cytoplasm and nucleus and its expression is
developmentally regulated. Alternative splicing results in multiple
transcript variants encoding different isoforms. [provided by
RefSeq].
Background References:
- Holz-Schietinger, C., et al. J. Biol. Chem. 285(38):29091-29100(2010)
- Kelemen, L.E., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1822-1830(2010)
- Park, C.W., et al.Cardiovasc Transl Res 3(3):290-295(2010)
- Haggarty, P., et al. PLoS ONE(6), E11329 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Immunogen:
This DNMT3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from the Central region of human DNMT3A.
NCBI Gene ID #:
1788
NCBI Official Name:
DNA (cytosine-5)-methyltransferase 3A
NCBI Official Symbol:
DNMT3A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
102 kDa
Protein Accession #:
Q9Y6K1
Protein GI Number:
166215081
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9Y6K1
User NOte:
Optimal dilutions for each application to be determined by the researcher.