DNMT3L Antibody
| Code | Size | Price |
|---|
| PSI-58-575-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
DNA (cytosine-5)-methyltransferase 3-like, DNMT3L
Application Note:
For WB starting dilution is: 1:1000
Background:
CpG methylation is an epigenetic modification that is
important for embryonic development, imprinting, and X-chromosome
inactivation. Studies in mice have demonstrated that DNA
methylation is required for mammalian development. This gene
encodes a nuclear protein with similarity to DNA
methyltransferases. This protein is not thought to function as a
DNA methyltransferase as it does not contain the amino acid
residues necessary for methyltransferase activity. However, this
protein does stimulate de novo methylation by DNA cytosine
methyltransferase 3 alpha and it is thought to be required for the
establishment of maternal genomic imprints. This protein also
mediates transcriptional repression through interaction with
histone deacetylase 1. Alternative splicing results in two
transcript variants. An additional splice variant has been
described but its biological validity has not been determined.
Background References:
- Holz-Schietinger, C., et al. J. Biol. Chem. 285(38):29091-29100(2010)
- Manderwad, G.P., et al. Arch. Pathol. Lab. Med. 134(8):1193-1196(2010)
- Kim, H., et al. Int. J. Oncol. 36(6):1563-1572(2010)
- Minami, K., et al. Clin. Cancer Res. 16(10):2751-2759(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DNMT3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-381 amino acids from the C-terminal region of human DNMT3L.
NCBI Gene ID #:
29947
NCBI Official Name:
DNA (cytosine-5)-methyltransferase 3-like
NCBI Official Symbol:
DNMT3L
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
44 kDa
Protein Accession #:
Q9UJW3
Protein GI Number:
334302913
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9UJW3
User NOte:
Optimal dilutions for each application to be determined by the researcher.