CBX5 Antibody
| Code | Size | Price |
|---|
| PSI-57-266-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a highly conserved nonhistone protein,
which is a member of the heterochromatin protein family. The
protein is enriched in the heterochromatin and associated with
centromeres. The protein has a single N-terminal chromodomain which
can bind to histone proteins via methylated lysine residues, and a
C-terminal chromo shadow-domain (CSD) which is responsible for the
homodimerization and interaction with a number of
chromatin-associated nonhistone proteins. The encoded product is
involved in the formation of functional kinetochore through
interaction with essential kinetochore proteins. The gene has a
pseudogene located on chromosome 3. Multiple alternatively spliced
variants, encoding the same protein, have been identified.
Background References:
- Nozawa, R.S., et al. Nat. Cell Biol. 12(7):719-727(2010)
- Zeng, W., et al. Epigenetics 5(4):287-292(2010)
- Emelyanov, A.V., et al. J. Biol. Chem. 285(20):15027-15037(2010)
- Kiyomitsu, T., et al. J. Cell Biol. 188(6):791-807(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human CBX5.
NCBI Gene ID #:
23468
NCBI Official Name:
Chromobox protein homolog 5
NCBI Official Symbol:
CBX5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Protein Accession #:
P45973
Protein GI Number:
1170338
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P45973
User NOte:
Optimal dilutions for each application to be determined by the researcher.