CIR Antibody

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ProSci
Product Code: PSI-57-540
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-57-540-400ul400ul£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody at 1:1000 at each lane.
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Western blot analysis of lysate from human placenta tissue lysate, using CIR Antibody at 1:1000 at each lane.

Documents

Further Information

Additional Names:
Corepressor interacting with RBPJ 1, CBF1-interacting corepressor, Recepin, CIR1, CIR
Application Note:
For WB starting dilution is: 1:1000
Background:
CIR may modulate splice site selection during alternative splicing of pre-mRNAs. It regulates transcription and acts as corepressor for RBPSUH. It recruits RBPSUH to the Sin3-histone deacetylase complex (HDAC), and is required for RBPSUH-mediated repression of transcription.
Background References:
  • Olsen,J.V., Cell 127 (3), 635-648 (2006)
  • Maita,H., Exp. Cell Res. 303 (2), 375-387 (2005)
  • Zhou,S., Mol. Cell. Biol. 21 (18), 6222-6232 (2001)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-424 amino acids from the C-terminal region of human CIR.
NCBI Gene ID #:
9541
NCBI Official Name:
Corepressor interacting with RBPJ 1
NCBI Official Symbol:
CIR1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Protein Accession #:
Q86X95
Protein GI Number:
74727790
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q86X95
User NOte:
Optimal dilutions for each application to be determined by the researcher.