SPOP Antibody
| Code | Size | Price |
|---|
| PSI-60-100-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Speckle-type POZ protein, HIB homolog 1, Roadkill homolog 1, SPOP
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a protein that may modulate the
transcriptional repression activities of death-associated protein 6
(DAXX), which interacts with histone deacetylase, core histones,
and other histone-associated proteins. In mouse, the encoded
protein binds to the putative leucine zipper domain of macroH2A1.2,
a variant H2A histone that is enriched on inactivated X
chromosomes. The BTB/POZ domain of this protein has been shown in
other proteins to mediate transcriptional repression and to
interact with components of histone deacetylase co-repressor
complexes. Alternative splicing of this gene results in multiple
transcript variants encoding the same protein. [provided by
RefSeq].
Background References:
- Rose, J. Phd, et al. Mol. Med. (2010) In press :
- Zhuang, M., et al. Mol. Cell 36(1):39-50(2009)
- Liu, J., et al. Science 323(5918):1218-1222(2009)
- Bunce, M.W., et al. J. Biol. Chem. 283(13):8678-8686(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Zebrafish, Mouse
Immunogen:
This SPOP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the N-terminal region of human SPOP.
NCBI Gene ID #:
8405
NCBI Official Name:
Speckle-type POZ protein
NCBI Official Symbol:
SPOP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
42 kDa
Protein Accession #:
O43791
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O43791
User NOte:
Optimal dilutions for each application to be determined by the researcher.