SF3B3 Antibody
| Code | Size | Price |
|---|
| PSI-56-592-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Splicing factor 3B subunit 3, Pre-mRNA-splicing factor SF3b 130 kDa subunit, SF3b130, STAF130, Spliceosome-associated protein 130, SAP 130, SF3B3, KIAA0017, SAP130
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes subunit 3 of the splicing factor 3b
protein complex. Splicing factor 3b, together with splicing factor
3a and a 12S RNA unit, forms the U2 small nuclear
ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a
complex binds pre-mRNA upstream of the intron's branch site in a
sequence independent manner and may anchor the U2 snRNP to the
pre-mRNA. Splicing factor 3b is also a component of the minor
U12-type spliceosome. Subunit 3 has also been identified as a
component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase)
transcription coactivator-HAT (histone acetyltransferase) complex,
and the TFTC (TATA-binding-protein-free TAF(II)-containing
complex). These complexes may function in chromatin modification,
transcription, splicing, and DNA repair.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Will, C.L., et al. RNA 10(6):929-941(2004)
- Cavusoglu, N., et al. Proteomics 3(2):217-223(2003)
- Will, C.L., et al. EMBO J. 21(18):4978-4988(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SF3B3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1046-1074 amino acids from the C-terminal region of human SF3B3.
NCBI Gene ID #:
23450
NCBI Official Name:
Splicing factor 3B subunit 3
NCBI Official Symbol:
SF3B3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
136 kDa
Protein Accession #:
Q15393
Protein GI Number:
116242787
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q15393
User NOte:
Optimal dilutions for each application to be determined by the researcher.