CENPA Antibody
| Code | Size | Price |
|---|
| PSI-57-304-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA
Application Note:
For WB starting dilution is: 1:1000
Background:
Centromeres are the differentiated chromosomal domains
that specify the mitotic behavior of chromosomes. CENPA encodes a
centromere protein which contains a histone H3 related histone fold
domain that is required for targeting to the centromere. CENPA is
proposed to be a component of a modified nucleosome or
nucleosome-like structure in which it replaces 1 or both copies of
conventional histone H3 in the (H3-H4)2 tetrameric core of the
nucleosome particle. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq].
Background References:
- Sekulic, N., et al. Nature 467(7313):347-351(2010)
- Carroll, C.W., et al. J. Cell Biol. 189(7):1143-1155(2010)
- Maehara, K., et al. Mol. Cell. Biol. 30(9):2090-2104(2010)
- Buscaino, A., et al. Curr. Opin. Genet. Dev. 20(2):118-126(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Hamster
Immunogen:
This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the Central region of human CENPA.
NCBI Gene ID #:
1058
NCBI Official Name:
Histone H3-like centromeric protein A
NCBI Official Symbol:
CENPA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
16 kDa
Protein Accession #:
P49450
Protein GI Number:
1345726
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
P49450
User NOte:
Optimal dilutions for each application to be determined by the researcher.