SAP18 Antibody
| Code | Size | Price |
|---|
| PSI-58-153-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18, SAP18
Application Note:
For WB starting dilution is: 1:1000
Background:
Histone acetylation plays a key role in the regulation of
eukaryotic gene expression. Histone acetylation and deacetylation
are catalyzed by multisubunit complexes. The protein encoded by
this gene is a component of the histone deacetylase complex, which
includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other
polypeptides. This protein directly interacts with SIN3 and
enhances SIN3-mediated transcriptional repression when tethered to
the promoter. A pseudogene has been identified on chromosome 2.
Background References:
- Sorin, M., et al. PLoS Pathog.(6), E1000463 (2009) :
- McCallum, S.A., et al. Biochemistry 45(39):11974-11982(2006)
- Joselin, A.P., et al. J. Biol. Chem. 281(18):12475-12484(2006)
- Schwerk, C., et al. Mol. Cell. Biol. 23(8):2981-2990(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human SAP18.
NCBI Gene ID #:
10284
NCBI Official Name:
Histone deacetylase complex subunit SAP18
NCBI Official Symbol:
SAP18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
18 kDa
Protein Accession #:
O00422
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
O00422
User NOte:
Optimal dilutions for each application to be determined by the researcher.