SUV39H2 Antibody
| Code | Size | Price |
|---|
| PSI-60-326-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Histone-lysine N-methyltransferase SUV39H2, Histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2, KMT1B
Application Note:
For WB starting dilution is: 1:1000
Background:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.
Background References:
- Sun, X.J., et al. PLoS ONE(1), E1499 (2008) :
- Wu, C., et al. Proteomics 7(11):1775-1785(2007)
- Yoon, K.A., et al. Carcinogenesis 27(11):2217-2222(2006)
- Frontelo, P., et al. Oncogene 23(30):5242-5251(2004)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Monkey, Mouse
Immunogen:
This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 367-395 amino acids from the C-terminal region of human SUV39H2.
NCBI Gene ID #:
79723
NCBI Official Name:
Histone-lysine N-methyltransferase SUV39H2
NCBI Official Symbol:
SUV39H2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
Q9H5I1
Protein GI Number:
25091325
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Swissprot #:
Q9H5I1
User NOte:
Optimal dilutions for each application to be determined by the researcher.